Areas of expertise
Research across the MIB is clustered into seven distinct areas of expertise. These areas offer a way to bring our skills together on cross-disciplinary and collaborative projects.
Find out more about our areas of expertise, the capabilities of our research teams, and the facilities that support our work.
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Bioanalytical techniques
We use various bioanalytical techniques to support our research. This spans techniques such as mass spectrometry, nuclear magnetic resonance, and proteomics.
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Bioprocessing and biopharmaceutical development
Our work involves generating predictive design of new protein entities and increasing understanding of their suitability for potential therapeutic use.
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Biosynthetic pathway design and optimisation
We use a broad range of synthetic biology tools and technologies, such as computational design tools, and new fully integrated robotics platform for directed evolution and synthetic biology workflows.
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Directed evolution and molecular design
We have access to automation platforms for high throughput directed evolution (DE) and enzyme screening workflows, as well as robotics platforms for automated SELEX protocols.
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Modelling and data science
We have established expertise for in silico enzymology, including molecular dynamics simulation simulations. Our researchers use computational methods from density-functional theory to molecular mechanics, and hybrid quantum-mechanics / molecular-mechanics approaches.
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Structural biology and biophysics
Our researchers have expertise in a wide range of instruments for time resolved and structural analysis of proteins and enzymes.
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Synthetic genomics and strain engineering
Major MIB research programmes are developing and utilising synthetic biology protocols to engineer industrially relevant microbial production strains. In addition, we have expertise in yeast evolutionary genomics and development of synthetic yeast genomes.
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Understanding and harnessing biological catalysis
Enzymes or biocatalysts, are used in a variety of industrial applications and processes. MIB research ranges from structural and mechanistic understanding of biological catalysts through to the discovery, engineering and optimisation of enzymes.
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